Publications
Urea cycle modulation by combined SGLT2 inhibitors and metformin
Makoto Harada, Jonathan Adam, Siyu Han, Mengya Shi, Jianhong Ge, Jutta Lintelmann, Alexander Cecil, Sven Zukunft, Cornelia Prehn, Michael Witting, Markus F Scheerer, Susanne Neschen, Martin Irmler, Johannes Beckers, Jerzy Adamski, Daniel Teupser, Birgit Linkohr, Christian Gieger, Martin Hrabě de Angelis, Annette Peters, Rui Wang-Sattler
BMC Med. 2026 Jan 8;24(1):55. PMID: 41501827
Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteries
Jessica Pauli, Daniel Garger, Fatemeh Peymani, Justus Wettich, Nadja Sachs, Johannes Wirth, Katja Steiger, Hanrui Zhang, Ira Tabas, Alan Tall, Mingyao Li, Muredach P. Reilly, Daniela Branzan, Holger Prokisch, Michael P. Menden, Lars Maegdefessel
Nat Commun. 2025 Dec 18;16(1):11282. PMID: 41413386
Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure - interaction between loss of Y chromosome and clonal haematopoiesis
Sebastian Cremer, Moritz von Scheidt, Klara Kirschbaum, Lukas Tombor, Silvia Mas-Peiro, Wesley Abplanalp, Tina Rasper, Akshay Ware, Andrin Schuff, Alexander Berkowitsch, Johannes Krefting, David Leistner, Heribert Schunkert, Thimoteus Speer, Stefanie Dimmeler, Andreas Michael Zeiher
Eur J Heart Fail. 2025 Dec;27(12):3219-3234. PMID: 40702883
Correction: Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data
Johannes Krefting, Christian Graesser, Sophie Novacek, Felix Voll, Aldo Moggio, Nils Krueger, Christian Friess, Marius Schwab, Frank Offenborn, Teresa Trenkwalder, Sebastian Kufner, Erion Xhepa, Michael Joner, Salvatore Cassese, Heribert Schunkert, Gjin Ndrepepa, Adnan Kastrati, Moritz von Scheidt, Thorsten Kessler, Hendrik B Sager
Clin Res Cardiol. 2025 Dec;114(12):1768. PMID: 40387893
Hypertension and kidney dysfunction despite long-term remission of Cushing's syndrome
Katrin Ritzel, Vanessa Fedtke, Cornelia Then, Elisabeth Nowak, Frederick Vogel, Leah Braun, Stephanie Zopp, Petra Zimmermann, Annette Peters, Margit Heier, Birgit Linkohr, Michael Roden, Martin Bidlingmaier, Felix Beuschlein, Martin Reincke, German Rubinstein
J Endocrinol Invest. 2025 Nov;48(11):2671-2681. PMID: 40728707
AlphaDIA enables DIA transfer learning for feature-free proteomics
Georg Wallmann, Patricia Skowronek, Vincenth Brennsteiner, Mikhail Lebedev, Marvin Thielert, Sophia Steigerwald, Mohamed Kotb, Oscar Despard, Tim Heymann, Xie-Xuan Zhou, Maximilian T Strauss, Constantin Ammar, Sander Willems, Magnus Schwörer, Wen-Feng Zeng, Matthias Mann
Nat Biotechnol. 2025 Oct 21. PMID: 41120665
Cohort Profile: Cooperative Health Research in the Region of Augsburg (KORA) 1984-2024
Birgit Linkohr, Margit Heier, Christian Gieger, Barbara Thorand, Harald Grallert, Rolf Holle, Stefan Karrasch, Wolfgang Koenig, Karl-Heinz Ladwig, Michael Laxy, Bettina Lorenz-Depiereux, Susanne Rospleszcz, Alexandra Schneider, Holger Schulz, Lars Schwettmann, Marie Standl, Melanie Waldenberger, Rui Wang-Sattler, Kathrin Wolf, Marco Dallavalle, Ina-Maria Rückert-Eheberg, Andrea Schneider, Reiner Leidl, Heinz-Erich Wichmann, Annette Peters
Int J Epidemiol. 2025 Oct 14;54(6):dyaf187. PMID: 41208172
Integrated single-cell atlas of human atherosclerotic plaques
Korbinian Traeuble, Matthias Munz, Jessica Pauli, Nadja Sachs, Eshan Vafadarnejad, Tania Carrillo-Roa, Lars Maegdefessel, Peter Kastner, Matthias Heinig
Nat Commun. 2025 Sep 10;16(1):8255. PMID: 40931012
A Novel Hybrid High-Speed Mass Spectrometer Allows Rapid Translation From Biomarker Candidates to Targeted Clinical Tests Using 15N-Labeled Proteins
Maria Wahle, Philip M Remes, Vincent Albrecht, Michael Baggio Lorenz, Johannes Mueller-Reif, Sophia Steigerwald, Tim Heymann, Lili Niu, Philip Lössl, Stevan Horning, Cristina C Jacob, Matthias Mann
Mol Cell Proteomics. 2025 Sep;24(9):101050. PMID: 40816420
Clonal hematopoiesis of indeterminate potential and mortality in coronary artery disease
Moritz von Scheidt, Shaunak S Adkar, Johannes Krefting, Gregor Hoermann, Manja Meggendorfer, Sabine Bauer, Shaneice Mitchell, Irina Pugach, Christian Friess, Angela Ma, Ke Hao, Sophia Steigerwald, Maria Wahle, Thorsten Kessler, Marius Schwab, Felix Voll, Michal Mokry, Charalampos Sofokleous, Kaylin C A Palm, Dario Bongiovanni, Julia Fleig, Lilith Oldenbuettel, Zhifen Chen, Judith S Hecker, Florian Bassermann, Lars Maegdefessel, Matthias Graw, Arno Ruusalepp, Ingo Hilgendorf, Florian Leuschner, Hendrik B Sager, J Brett Heimlich, Wolfgang Koenig, Sebastian Cremer, David M Leistner, Wesley T Abplanalp, Stefanie Dimmeler, Andreas M Zeiher, Sander W van der Laan, Gerard Pasterkamp, Christian Braun, Siddhartha Jaiswal, Jason C Kovacic, Wolfgang Kern, Claudia Haferlach, Matthias Mann, Salvatore Cassese, Adnan Kastrati, Torsten Haferlach, Nicholas J Leeper, Johan L M Björkegren, Heribert Schunkert
Eur Heart J 2025 Sep 3:ehaf602. PMID: 40900105
A macrophage gene-regulatory network linked to clinical severity of coronary artery disease: The STARNET and NGS-PREDICT primary blood macrophage studies
Lijiang Ma, Jacqueline E Tamis-Holland, Giuseppe Mocci, Kathryn Wolhuter, Nicole S Bryce, Swathy Sajja, Letizia Amadori, Payal Pradhan, Peik Sean Chong, Katyayani Sukhavasi, Haoxiang Cheng, Ling Li, Shichao Pang, Eric E Schadt, Heribert Schunkert, Moritz von Scheidt, Arno Ruusalepp, Pedro R Moreno, Ke Hao, Chiara Giannarelli, Clint L Miller, Jason C Kovacic, Johan L M Björkegren
Basic Res Cardiol. 2025 Aug;120(4):799-814. PMID: 40590916
Associations of road traffic noise with adipose tissue depots and hepatic fat content - Results from the German National Cohort (NAKO)
Fiona Niedermayer, Susanne Rospleszcz, Clara Matthiessen, Barbara Hoffmann, Sophia Stoecklein, Tobias Haueise, Tobias Norajitra, Christopher L Schlett, Johanna Nattenmüller, Fabian Bamberg, Jürgen Machann, Matthias Günther, Jochen Hirsch, Rajini Nagrani, Henry Völzke, Claudia Meinke-Franze, Norbert Hosten, Tobias Nonnenmacher, Bettina Katalin Budai, Viktoria Palm, Verena Katzke, Karin Halina Greiser, Jeanette Schulz-Menger, Thoralf Niendorf, Beate Endemann, Tobias Pischon, Jeroen Staab, Marco Dallavalle, Alexandra Schneider, Kathrin Wolf, Annette Peters
Environ Int. 2025 Jul:201:109566. PMID: 40460707
Clinical scores fail to sufficiently identify children with Familial Hypercholesterolemia
Raphael S Schmieder, Johannes Krefting, Sara Ates, Lea D Schlieben, Stefan Arens, Olga Kordonouri, Michaela Sander, Stefan Holdenrieder, Volker Mall, Thomas Meitinger, Moritz von Scheidt, Wolfgang Koenig, Georg Leipold, Holger Prokisch, Heribert Schunkert, Veronika Sanin
Eur J Prev Cardiol, 2025 Jul 9:zwaf301. PMID: 40632909
Machine learning approach on plasma proteomics identifies signatures associated with obesity in the KORA FF4 cohort
Jiefei Niu, Jonathan Adam, Thomas Skurk, Jochen Seissler, Qiuling Dong, Esienanwan Efiong, Christian Gieger, Annette Peters, Sapna Sharma, Harald Grallert
Diabetes Obes Metab. 2025 May;27(5):2626-2636. PMID: 40017018
Cloud Performance in Healthcare: A Benchmarking and Analysis Study of the DigiMed Bayern Cloud
Wehrig J. Bachelor Thesis.
April 2025
DigiMed Trusted Research Environment: Strategic Market Positioning for Healthcare Sovereignty, Privacy, and Utility of Medical Data
Sfar Y. Bachelor Thesis.
April 2025
Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics
Xiang Zheng, Andreas Mund, Matthias Mann
Mol Cell. 2025 Mar 6;85(5):1008-1023.e7. PMID: 39814024
Early detection of familial hypercholesterolemia: The Vroni study [Article in German]
Veronika Sanin, Heribert Schunkert
MMW Fortschr Med. 2025 Mar;167(5):56-59. PMID: 40113704
Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data
Johannes Krefting, Christian Graesser, Sophie Novacek, Felix Voll, Aldo Moggio, Nils Krueger, Christian Friess, Marius Schwab, Frank Offenborn, Teresa Trenkwalder, Sebastian Kufner, Erion Xhepa, Michael Joner, Salvatore Cassese, Heribert Schunkert, Gjin Ndrepepa, Adnan Kastrati, Moritz von Scheidt, Thorsten Kessler & Hendrik B. Sager
Clin Res Cardiol 2025 Mar 20. PMID: 40111442
Role of genetics in precision medicine of coronary artery disease
V. Sanin, R. S. Schmieder, W. Koenig, L. Li, H. Schunkert, Z. Chen
Herz, Schwerpunkt, Published: 28 February 2025, Volume 50, pages 79–87, (2025)
Spatially resolved proteomic signatures of atherosclerotic carotid artery disease
Ankit Sinha, Nadja Sachs, Elena Kratz, Jessica Pauli, Sophia Steigerwald, Vincent Albrecht, Thierry Nordmann, Enes Ugur, Edwin H Rodriguez, Marie-Luise Engl, Patricia Skowronek, Moritz von Scheidt, Hanna Winter, Daniela Branzan, Heribert Schunkert, Lars Maegdefessel, Matthias Mann
medRxiv
Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease
Teresa Trenkwalder, Carlo Maj, Baravan Al-Kassou, Radoslaw Debiec, Stefanie A Doppler, Muntaser D Musameh, Christopher P Nelson, Pouria Dasmeh, Sandeep Grover, Katharina Knoll, Joonas Naamanka, Ify R Mordi, Peter S Braund, Martina Dreßen, Harald Lahm, Felix Wirth, Stephan Baldus, Malte Kelm, Moritz von Scheidt, Johannes Krefting, David Ellinghaus, Aeron M Small, Gina M Peloso, Pradeep Natarajan, George Thanassoulis, James C Engert, Line Dufresne, Andre Franke, Siegfried Görg, Matthias Laudes, Ulrike Nowak-Göttl, Mariliis Vaht, Andres Metspalu, Monika Stoll, Klaus Berger, Costanza Pellegrini, Adnan Kastrati, Christian Hengstenberg, Chim C Lang, Thorsten Kessler, Iiris Hovatta, Georg Nickenig, Markus M Nöthen, Markus Krane, Heribert Schunkert, Nilesh J Samani, Johannes Schumacher, Mart Kals, Anu Reigo, Maris Teder-Laving, Jan Gehlen, Thomas R Webb, Ann-Sophie Giel, Laura L Koebbe, Nina Feirer, Maximilian Billmann, Sundar Srinivasan, Sebastian Zimmer, Colin N A Palmer, Ling Li, Chuhua Yang, Oleg Borisov, Matti Adam, Verena Veulemans, Michael Joner, Erion Xhepa
JAMA Cardiol. 2025 Feb 1;10(2):145-154. PMID: 39504041, PMCID: PMC11541746
Long Non-Coding RNA Function in Smooth Muscle Cell Plasticity and Atherosclerosis
Maegdefessel L, Fasolo F. . Epub 2024 Dec 5. PMID: 39633574; PMCID: PMC11748911.
Arterioscler Thromb Vasc Biol., 2025 Feb;45(2):172-185.
doi: 10.1161/ATVBAHA.124.320393
Nachweis und Bedeutung von Leukozyten mit klonaler Hämatopoese von unbestimmtem Potential (CHIP) im humanen atherosklerotischen Plaque
Fleig J. Dissertation.
Januar 2025
Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study
Lai L, Juntilla DL, Del M, Del C Gomez-Alonso M, Grallert H, Thorand B, Farzeen A, Rathmann W, Winkelmann J, Prokisch H, Gieger C, Herder C, Peters A, Waldenberger M. . PMID: 39827095; PMCID: PMC11748594.
Cardiovasc Diabetol., 2025 Jan 18;24(1):19
doi: 10.1186/s12933-024-02558-8
Book Chapter: Das Herz und die politische Rationalität
Therese Feiler
in: Das Herz: Perspektiven auf die Mitte des Menschen zwischen Glaube und Vernunft, Therese Feiler und Peter Schüz (Hg.), Brill/Schöningh, 2024, S. 303-338.
Book Chapter: Wissenschaft und Theologie – Theologizität der Wissenschaft. Zur Vermittlung zwischen den Disziplinen bei Wolfhart Pannenberg und John Milbank
Therese Feiler
in: Gunter Wenz (Hg.), Die Wissenschaft von Gott und ihre Disziplinen. Zu Wolfhart Pannenbergs Theologieverständnis, Göttingen: Vandenhoeck & Ruprecht, 2024, S. 175-192.
AlphaPept: a modern and open framework for MS-based proteomics
Maximilian T. Strauss, Isabell Bludau, Wen-Feng Zeng, Eugenia Voytik, Constantin Ammar, Julia P. Schessner, Rajesh Ilango, Michelle Gill, FlorianMeier, Sander Willems & Matthias Mann
Nat Commun, 15, 2168 (2024)
A novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N labeled proteins
Maria Wahle, Philip M. Remes, Vincent Albrecht, Johannes Mueller-Reif, Sophia Steigerwald, Tim Heymann, Lili Niu, Philip Lössl, Stevan Horning, Cristina C. Jacob, Matthias Mann
bioRxiv, 2024.06.02.597029
AlphaDIA enables End-to-End Transfer Learning for Feature-Free Proteomics
Georg Wallmann, Patricia Skowronek, Vincenth Brennsteiner, Mikhail Lebedev, Marvin Thielert, Sophia Steigerwald, Mohamed Kotb, Tim Heymann, Xie-Xuan Zhou, Magnus Schwörer, Maximilian T. Strauss, Constantin Ammar, Sander Willems, Wen-Feng Zeng, Matthias Mann
bioRxiv, 2024.05.28.596182
AlphaViz: Visualization and validation of critical proteomics data directly at the raw data level
Eugenia Voytik, Patricia Skowronek, Wen-Feng Zeng, Maria C. Tanzer, Andreas-David Brunner, Marvin Thielert, Maximilian T. Strauss, Sander Willems, Matthias Mann
bioRxiv, 2022.07.12.499676
Association of plasma proteomics with mortality in individuals with and without type 2 diabetes: Results from two population-based KORA cohort studies
Hong Luo, Agnese Petrera, Stefanie M. Hauck, Wolfgang Rathmann, Christian Herder, Christian Gieger, Annika Hoyer, Annette Peters, Barbara Thorand
BMC Med. 2024 Sep 27;22(1):420
Ticagrelor vs Prasugrel for Acute Coronary Syndrome in Routine Care
Nils Krüger, MD; Johannes Krefting, MD; Thorsten Kessler, MD; Raphael Schmieder, MD; Fabian Starnecker, MD; Alexander Dutsch, MD; Christian Graesser, MD; Ulrike Meyer-Lindemann, MD; Theresa Storz, MD; Irina Pugach, PhD; Christian Frieß, MD; Zhifen Chen, PhD; Dario Bongiovanni, MD3; Iulian Manea, BSc; Tobias Dreischulte, PhD; Frank Offenborn6; Peter Krase6; Hendrik B. Sager, MD; Jens Wiebe, MD; Sebastian Kufner, MD; Erion Xhepa, MD, PhD; Michael Joner, MD; Teresa Trenkwalder, MD; Ulrich Gueldener, PhD; Adnan Kastrati, MD; Salvatore Cassese, MD; Heribert Schunkert, MD; Moritz von Scheidt, MD; for the DigiMed Bayern Consortium
JAMA Netw Open. 2024;7(12):e2448389
The German version of the mHealth App Usability Questionnaire (GER-MAUQ): Translation and validation study in patients with cardiovascular disease
Theodora Tacke, Pascal Nohl-Deryk, Neelam Lingwal, Lara Marie Reimer, Fabian Starnecker, Corina Güthlin, Ferdinand M Gerlach, Heribert Schunkert, Stephan Jonas, Angelina Müller
DIGITAL HEALT, 2024;10
Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease
Rainer Malik, Nathalie Beaufort, Jiang Li, Koki Tanaka, Marios K. Georgakis, Yunye He, Masaru Koido, Chikashi Terao, BioBank Japan, Christopher D. Anderson, Yoichiro Kamatani, Ramin Zand & Martin Dichgans
Nat Cardiovasc Res
Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease
Li L, Pang S, Starnecker F, Mueller-Myhsok B, Schunkert H.
Eur Heart J., 2024 Mar 29
User-centered development of an mHealth app for cardiovascular prevention
Lara Marie Reimer, Leon Nissen , Moritz von Scheidt, Benedikt Perl, Jens Wiehler, Sinann Al Najem, Florian P. Limbourg, Theodora Tacke, Angelina Müller, Stephan Jonas, Heribert Schunkert, Fabian Starnecker
DIGITAL HEALTH, 2024;10
Plasma proteome association with coronary heart disease and carotid intima media thickness: results from the KORA F4 study
Elhadad MA, Del C Gómez-Alonso M, Chen CW, Neumeyer S, Delerue T, Rathmann W, Näbauer M, Meisinger C, Kääb S, Seissler J, Graumann J, Koenig W, Suhre K, Gieger C, Völker U, Peters A, Hammer E, Waldenberger M.
Cardiovasc Diabetol., 2024 May 29;23(1):181
Early action, lifelong impact: the crucial role of early detection, risk stratification, and aggressive treatment of familial hypercholesterolaemia
Veronika Sanin, Raphael S Schmieder, Wolfgang Koenig
European Journal of Preventive Cardiology, online publish-ahead-of-print 20 February 2024
Hypertension in the first blood pressure reading and the risk of cardiovascular disease mortality in the general population: findings from the prospective KORA study
Seryan Atasoy , Peter Henningsen, Hamimatunnisa Johar , Martin Middeke, Heribert Sattel, Birgit Linkohr, Ina-Maria Rückert-Eheberg, Margit Heier, Annette Peters, Karl-Heinz Ladwig
J Hypertens, 2024 Mar 1;42(3):521-529.
Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis
Sophia Steigerwald, Ankit Sinha, Kyle L. Fort, Wen-Feng Zeng, Lili Niu, Christoph
Molecular & Cellular Proteomics, 3 January 2024
Guideline-Based Cardiovascular Risk Assessment Delivered by an mHealth App: Development Study
Starnecker F, Reimer L, Nissen L, Jovanović M, Kapsecker M, Rospleszcz S, von Scheidt M, Krefting J, Krüger N, Perl B, Wiehler J, Sun R, Jonas S, Schunkert H
JMIR CARDIO, 2023 Dec 8;7:e50813
IMBAS-MS Discovers Organ-Specific HLA Peptide Patterns in Plasma
Maria Wahle, Marvin Thielert, Maximilian Zwiebel, Patricia Skowronek, Wen-Feng Zeng, Matthias Mann
Mol Cell Proteomics, 2023 Dec 1:100689
Unique 40-year survival after heart transplantation with normal graft function and spontaneous operational tolerance
Wolfgang von Scheidt, Bruno Reichart, Bruno Meiser, Moritz von Scheidt, Partho Sen, Florian Schwarz, Eva Harmel, Frank M. Bengel, Andrea Dick, Peter Ueberfuhr, Hermann Reichenspurner, Elmar Jaeckel, Reinhard Schwinzer & Christian Hagl
Res Cardiol, Published 20 November 2023
Utilization of an Artery-on-a-Chip to Unravel Novel Regulators and Therapeutic Targets in Vascular Diseases
Paloschi V, Pauli J, Winski G, Wu Z, Li Z, Botti L, Meucci S, Conti P, Rogowitz F, Glukha N, Hummel N, Busch A, Chernogubova E, Jin H, Sachs N, Eckstein HH, Dueck A, Boon RA, Bausch AR, Maegdefessel L.
Adv Healthc Mater, 2023 Oct 5
Robust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Thielert M, Itang EC, Ammar C, Rosenberger FA, Bludau I, Schweizer L, Nordmann TM, Skowronek P, Wahle M, Zeng WF, Zhou XX, Brunner AD, Richter S, Levesque MP, Theis FJ, Steger M, Mann M.
Mol Syst Biol, 2023 Aug 21:e11503 irc Res, 2023 Sep 7
Detecting Differential Alternative Splicing in Mass Spectrometry-based Proteomics Data
Constanin Ammar, Gergely Csaba, Armin Hadziahmetovic, Catherine G. Vasilopoulou, Markus Gruber, Matthias Mann and Ralf Zimmer
bioRxiv, preprint September 22, 2023
ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1
Amin Sharifi M, Wierer M, An Dang T, Milic J, Moggio A, Sachs N, von Scheidt M, Hinterdobler J, Müller P, Werner J, Stiller B, Aherrahrou Z, Erdmann J, Zaliani A, Graettinger M, Reinshagen J, Gul S, Gribbon P, Maegdefessel L, Bernhagen J, Sager HB, Mann M, Schunkert H, Kessler T.
Circ Res, 2023 Sep 7, Epub ahead of print
Integrative omics approaches to advance raredisease diagnostics
Dmitrii Smirnov, Nikita Konstantinovskiy, Holger Prokisch
Journal of Inherited Metabolic Disease, 46:824–838
The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms
Fasolo F, Winski G, Li Z, Wu Z, Winter H, Ritzer J, Glukha N, Roy J, Hultgren R, Pauli J, Busch A, Sachs N, Knappich C, Eckstein HH, Boon RA, Paloschi V, Maegdefessel L.
Molecular Therapy: Nucleic Acids, Volume 33, P848-865
Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques
Scheidt M, Bauer S, Ma A, Hao K, Kessler T, Vilne B, Wang Y, Hodonsky CJ, Ghosh SKB, Mokry M, Gao H, Kawai K, Sakamoto A, Kaiser J, Bongiovanni D, Fleig J, Oldenbuettel L, Chen Z, Moggio A, Sager HB, Hecker JS, Bassermann F, Maegdefessel L, Miller CL, Koenig W, Zeiher AM, Dimmeler S, Graw M, Braun C, Ruusalepp A, Leeper NJ
medRxiv, [Preprint]. 2023 Jul
Towards Confidential Computing: A Secure Cloud Architecture for Big Data Analytics and AI
N. Zhou, F. Dufour, V. Bode, P. Zinterhof, N. J. Hammer, and D. Kranzlmüller
2023 IEEE 16th International Conference on Cloud Computing (IEEE CLOUD), Chicago, Illinois, USA, July 2-8, 2023
doi.org/10.48550/arXiv.2305.17761
Medikalisierte Lebensführung und soziale Ungleichheit. Kooperationsperspektiven von P4-Medizin und Sozialer Arbeit
Arne Dreßler, Oliver Dimbath
In: Schübel, Thomas/Friele, Boris (Hg.): Medikalisierung und Soziale Arbeit, Springer VS, S. 203–221
Long non-coding RNAs at the crossroad of vascular smooth muscle cell phenotypic modulation in atherosclerosis and neointimal formation
Francesca Fasolo, Valentina Paloschi, Lars Maegdefessel
Atherosclerosis, 374, 34-43
Accurate label-free quantification by directLFQ to compare unlimited numbers of proteomes
Constantin Ammar, Julia Patricia Schessner, Sander Willems, André C. Michaelis, Matthias Mann
Molecular & Cellular Proteomics, pe proof
E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1
Mulorz J, Spin JM, Mulorz P, Wagenhäuser MU, Deng A, Mattern K, Rhee YH, Toyama K, Adam M, Schelzig H, Maegdefessel L, Tsao PS.
Cardiovascular Research, 119, 867–878
Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression
Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, Bäcklund A, Khomtchouk BB, Van Booven DJ, Sachs N, Eckstein H-H, Wittig I, Boon RA, Jin H, Maegdefessel L
Molecular Therapy (2023, pre proof)
Use of big data from health insurance for assessment of cardiovascular outcomes
Johannes Krefting, Partho Sen, Diana David-Rus, Ulrich Güldener, Johann S Hawe, Moritz Von Scheidt, Salvatore Cassese, Heribert Schunkert.
Front. Artif. Intell. Sec. Medicine and Public Health, Volume 6 - 2023
Machine Learning Identifies New Predictors on Restenosis Risk after Coronary Artery Stenting in 10,004 Patients with Surveillance Angiography
Güldener, Ulrich, Thorsten Kessler, Moritz von Scheidt, Johann S. Hawe, Beatrix Gerhard, Dieter Maier, Mark Lachmann, Karl-Ludwig Laugwitz, Salvatore Cassese, Albert W. Schömig, Adnan Kastrati and Heribert Schunkert
Journal of Clinical Medicine, 2023; 12(8):2941
Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes
Yipeng Cheng, Danni A. Gadd, Christian Gieger, Karla Monterrubio-Gómez, Yufei Zhang, Imrich Berta, Michael J. Stam, Natalia Szlachetka, Evgenii Lobzaev , Nicola Wrobel, Lee Murphy, Archie Campbell, Cliff Nangle, Rosie M. Walker, Chloe Fawns-Ritchie, Annette Peters, Wolfgang Rathmann, David J. Porteous, Kathryn L. Evans, Andrew M. McIntosh, Timothy I. Cannings, Melanie Waldenberger, Andrea Ganna, Daniel L. McCartney, Catalina A. Vallejos & Riccardo E. Marioni
nature aging, Volume 3 | April 2023 | 450–458
A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study
Duschek E, Forer L, Schönherr S, Gieger C, Peters A, Kronenberg F, Grallert H, Lamina C.
Sci Rep., 2023 Mar 23;13(1):4805.
Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations
Thareja G, Belkadi A, Arnold M, Albagha OME, Graumann J, Schmidt F, Grallert H, Peters A, Gieger C, Consortium TQGPR, Suhre K.
Hum Mol Genet, 2023 Mar 6;32(6):907-916
Kontrollmedizin und Patientenautonomie. Das Freiheitsproblem in der gesundheitsorientierten medizinischen Versorgung, speziell bei der Einführung von Screenings.
Ein Dialog zwischen Allgemeiner Soziologie und Medizinsoziologie
Arne Dreßler und Oliver Dimbath
TTN Edition 2023 Freiheit, Institut Technik-Theologie-Naturwissenschaften (TTN)
an der Ludwig-Maximilians-Universität, Pages 25-41
https://www.ttn.st.evtheol.uni-muenchen.de/publikationen/ttn_edition/ttn_edition_2023_freiheit.pdf
Chapter 10 - Genetics of mitochondrial diseases: Current approaches for the molecular diagnosis
Lea D. Schlieben, Holger Prokisch
Handbook of Clinical Neurology, Elsevier, Volume 194, 2023, Pages 141-165
Genetic and modifiable risk factors combine multiplicatively in common disease
Pang S, Yengo L, Nelson CP, Bourier F, Zeng L, Li L, Kessler T, Erdmann J, Mägi R, Läll K, Metspalu A, Mueller-Myhsok B, Samani NJ, Visscher PM, Schunkert H
Clinical Research in Cardiology, 2023 Feb;112(2):247-257
Population-based screening in children for early diagnosis and treatment of familial hypercholesterolemia: design of the VRONI study
Veronika Sanin, Raphael Schmieder, Sara Ates, Lea Dewi Schlieben, Jens Wiehler, Ruoyu Sun, Manuela Decker, Michaela Sander, Stefan Holdenrieder, Florian Kohlmayer, Anna Friedmann, Volker Mall, Therese Feiler, Arne Dreßler, Tim M. Strom, Holger Prokisch, Thomas Meitinger, Moritz von Scheidt, Wolfgang Koenig, Georg Leipold, and Heribert Schunkert on behalf of the DigiMed Bayern Consortium and Bavarian Pediatricians Consortium
De Gruyter, medizinische genetik 2022; 34(1): 41–51
Synchro-PASEF allows precursor-specific fragment ion extraction and interference removal in data-independent acquisition
Skowronek P, Krohs F, Lubeck M, Wallmann G, Itang ECM, Koval P, Wahle M, Thielert M, Meier F, Willems S, Raether O, Mann M.
IMol Cell Proteomics, 2022 Dec 21:100489
Quo Vadis? Immunodynamics of Myeloid Cells after Myocardial Infarction
Moggio A, Schunkert H, Kessler T, Sager HB.
Int J Mol Sci, 2022 Dec 13;23(24)
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M, Hindy G, Zhou W, Grace C, Roselli C, Marston NA, Kamanu FK, Surakka I, Venegas LM, Sherliker P, Koyama S, Ishigaki K, Åsvold BO, Brown MR, Brumpton B, de Vries PS, Giannakopoulou O, Giardoglou P, Gudbjartsson DF, Güldener U, Haider SMI, Helgadottir A, Ibrahim M, Kastrati A, Kessler T, Kyriakou T, Konopka T, Li L, Ma L, Meitinger T, Mucha S, Munz M, Murgia F, Nielsen JB, Nöthen MM, Pang S, Reinberger T, Schnitzler G, Smedley D, Thorleifsson G, von Scheidt M, Ulirsch JC; Biobank Japan; EPIC-CVD, Arnar DO, Burtt NP, Costanzo MC, Flannick J, Ito K, Jang DK, Kamatani Y, Khera AV, Komuro I, Kullo IJ, Lotta LA, Nelson CP, Roberts R, Thorgeirsson G, Thorsteinsdottir U, Webb TR, Baras A, Björkegren JLM, Boerwinkle E, Dedoussis G, Holm H, Hveem K, Melander O, Morrison AC, Orho-Melander M, Rallidis LS, Ruusalepp A, Sabatine MS, Stefansson K, Zalloua P, Ellinor PT, Farrall M, Danesh J, Ruff CT, Finucane HK, Hopewell JC, Clarke R, Gupta RM, Erdmann J, Samani NJ, Schunkert H, Watkins H, Willer CJ, Deloukas P, Kathiresan S, Butterworth AS; CARDIoGRAMplusC4D Consortium.
Nature Genetics, 54, pages 1803–1815 (2022)
Linking single nucleotide polymorphisms to signaling blueprints in abdominal aortic aneurysms
Lim C, Pratama MY, Rivera C, Silvestro M, Tsao PS, Maegdefessel L, Gallagher KA, Maldonado T, Ramkhelawon B.
Scientific Reports, 2022 Dec 5;12(1):20990.
Radikale Medikalisierung: P4-Medizin als gesellschaftliches Modernisierungsprogramm
Arne Dreßler und Oliver Dimbath
Psychologie & Gesellschaftskritik, 46 (3), 91–110
->Link
Interleukin-1b suppression dampens inflammatory leucocyte production and uptake in atherosclerosis
Hettwer J, Hinterdobler J, Miritsch B, Deutsch MA, Li X, Mauersberger C, Moggio A, Braster Q, Gram H, Robertson AAB, Cooper MA, Groß O, Krane M, Weber C, Koenig W, Soehnlein O, Adamstein NH, Ridker P, Schunkert H, Libby P, Kessler T, Sager HB.
Cardiovascular Research, 2022 Oct 21;118(13):2778-2791
Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease
Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, Liu L, Ul Ain Q, Ehreiser V, Weber C, Kilani B, Mertsch P, Götschke J, Cremer S, Fu W, Lorenz M, Ishikawa-Ankerhold H, Raatz E, El-Nemr S, Görlach A, Marhuenda E, Stark K, Pircher J, Stegner D, Gieger C, Schmidt-Supprian M, Gaertner F, Almendros I, Kelm M, Schulz C, Hidalgo A, Massberg S.
Immunity, 2022 Oct 18:S1074-7613(22)00542-8
Genotypic and phenotypic spectrum of infantile liver failure due to pathogenic TRMU variants
Vogel GF, Mozer-Glassberg Y, Landau YE, Schlieben LD, Prokisch H, Feichtinger RG, Mayr JA, Brennenstuhl H, Schröter J, Pechlaner A, Alkuraya FS, Baker JJ, Barcia G, Baric I, Braverman N, Burnyte B, Christodoulou J, Ciara E, Coman D, Das AM, Darin N, Della Marina A, Distelmaier F, Eklund EA, Ersoy M, Fang W, Gaignard P, Ganetzky RD, Gonzales E, Howard C, Hughes J, Konstantopoulou V, Kose M, Kerr M, Khan A, Lenz D, McFarland R, Margolis MG, Morrison K, Müller T, Murayama K, Nicastro E, Pennisi A, Peters H, Piekutowska-Abramczuk D, Rötig A, Santer R, Scaglia F, Schiff M, Shagrani M, Sharrard M, Soler-Alfonso C, Staufner C, Storey I, Stormon M, Taylor RW, Thorburn DR, Teles EL, Wang JS, Weghuber D, Wortmann S.
Genet Med, 2022 Oct 28:S1098-3600(22)00953-4
Rapid and In-Depth Coverage of the (Phospho-)Proteome With Deep Libraries and Optimal Window Design for dia-PASEF
Skowronek P, Thielert M, Voytik E, Tanzer MC, Hansen FM, Willems S, Karayel O, Brunner AD, Meier F, Mann M
Mol Cell Proteomics, 2022 Sep;21(9)
Identification of risk loci for primary aldosteronism in genome-wide association studies
Le Floch E, Cosentino T, Larsen CK, Beuschlein F, Reincke M, Amar L, Rossi GP, De Sousa K, Baron S, Chantalat S, Saintpierre B, Lenzini L, Frouin A, Giscos-Douriez I, Ferey M, Abdellatif AB, Meatchi T, Empana JP, Jouven X, Gieger C, Waldenberger M, Peters A, Cusi D, Salvi E, Meneton P, Touvier M, Deschasaux M, Druesne-Pecollo N, Boulkroun S, Fernandes-Rosa FL, Deleuze JF, Jeunemaitre X, Zennaro MC
Nat Commun, 2022 Sep 3;13(1):5198
Association of In-Hospital Hemoglobin Drop With Decreased Myocardial Salvage and Increased Long-Term Mortality in Patients With Acute ST-Segment-Elevation Myocardial Infarction
Dutsch A, Graesser C, Voll F, Novacek S, Eggerstedt R, Armbruster NL, Laugwitz KL, Cassese S, Schunkert H, Ndrepepa G, Kastrati A, Kessler T, Sager HB
J Am Heart Assoc, 2022 Sep 6;11(17)
Genetic and modifiable risk factors combine multiplicatively in common disease
Pang S, Yengo L, Nelson CP, Bourier F, Zeng L, Li L, Kessler T, Erdmann J, Mägi R, Läll K, Metspalu A, Mueller-Myhsok B, Samani NJ, Visscher PM, Schunkert H.
Clinical Research in Cardiology, 2022 Aug 20
Colchicine Impacts Leukocyte Trafficking in Atherosclerosis and Reduces Vascular Inflammation
Meyer-Lindemann U, Mauersberger C, Schmidt AC, Moggio A, Hinterdobler J, Li X, Khangholi D, Hettwer J, Gräßer C, Dutsch A, Schunkert H, Kessler T, Sager HB.
Front Immunol., 2022 Jul 4; 13:898690
AlphaPeptDeep: A modular deep learning framework to predict peptide properties for proteomics
Wen-Feng Zeng, Xie-Xuan Zhou, Sander Willems, Constantin Ammar, Maria Wahle, Isabell Bludau, Eugenia Voytik, Maximillian T. Strauss and Matthias Mann.
bioRxiv preprint, online posted July 16, 2022
Chronically elevated branched chain amino acid levels are pro-arrhythmic
Portero V, Nicol T, Podliesna S, Marchal GA, Baartscheer A, Casini S, Tadros R, Treur JL, Tanck MWT, Cox IJ, Probert F, Hough TA, Falcone S, Beekman L, Müller-Nurasyid M, Kastenmüller G, Gieger C, Peters A, Kääb S, Sinner MF, Blease A, Verkerk AO, Bezzina CR, Potter PK, Remme CA.
Cardiovascular Research, 118, 1742–1757 (2022)
Association between a polygenic and family risk score on the prevalence and incidence of myocardial infarction in the KORA-F3 study
Florian Schnitzer, Lukas Forer, Sebastian Schönherr, Christian Gieger, Harald Grallert, Florian Kronenberg, Annette Peters, Claudia Lamina
atherosclerosis, Volume 352, P10-17, July 01, 2022
Guidelines for clinical interpretation of variant pathogenicity using RNA phenotypes
Dmitrii Smirnov, Lea D. Schlieben, Fatemeh Peymani, Riccardo Berutti, Holger Prokisch
Human Mutation Variation, Informatics and Disease. 29 May 2022
The structural context of posttranslational modifications at a proteome-wide scale
Isabell Bludau, Sander Willems, Wen-Feng Zeng, Maximilian T. Strauss, Fynn M. Hansen, Maria C. Tanzer, Ozge Karayel, Brenda A. Schulman, Matthias Mann
PLOS Biology. May 16, 2022
Validation of the 30-Year Framingham Risk Score in a German Population-Based Cohort
Rospleszcz S, Starnecker F, Linkohr B, von Scheidt M, Gieger C, Schunkert H, Peters A; DigiMed Bayern Consortium.
Diagnostics (Basel). 2022 Apr 12;12(4):965.
Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases
Li Y, Cheng Y, Consolato F, Schiano G, Chong MR, Pietzner M, Nguyen NQH, Scherer N, Biggs ML, Kleber ME, Haug S, Göçmen B, Pigeyre M, Sekula P, Steinbrenner I, Schlosser P, Joseph CB, Brody JA, Grams ME, Hayward C, Schultheiss UT, Krämer BK, Kronenberg F, Peters A, Seissler J, Steubl D, Then C, Wuttke M, März W, Eckardt KU, Gieger C, Boerwinkle E, Psaty BM, Coresh J, Oefner PJ, Pare G, Langenberg C, Scherberich JE, Yu B, Akilesh S, Devuyst O, Rampoldi L, Köttgen A.
JCI Insight. 2022 Apr 21;e157035.
Clinical implementation of RNA sequencing for Mendelian disease diagnostics
Yépez VA, Gusic M, Kopajtich R, Mertes C, Smith NH, Alston CL, Ban R, Beblo S, Berutti R, Blessing H, Ciara E, Distelmaier F, Freisinger P, Häberle J, Hayflick SJ, Hempel M, Itkis YS, Kishita Y, Klopstock T, Krylova TD, Lamperti C, Lenz D, Makowski C, Mosegaard S, Müller MF, Muñoz-Pujol G, Nadel A, Ohtake A, Okazaki Y, Procopio E, Schwarzmayr T, Smet J, Staufner C, Stenton SL, Strom TM, Terrile C, Tort F, Van Coster R, Vanlander A, Wagner M, Xu M, Fang F, Ghezzi D, Mayr JA, Piekutowska-Abramczuk D, Ribes A, Rötig A, Taylor RW, Wortmann SB, Murayama K, Meitinger T, Gagneur J, Prokisch H.
Genome Med. 2022; 14: 38.
Cis-epistasis at the LPA locus and risk of cardiovascular diseases
Lingyao Zeng, Sylvain Moser, Nazanin Mirza-Schreiber, Claudia Lamina, Stefan Coassin, Christopher P Nelson, Tarmo Annilo, Oscar Franzén, Marcus E Kleber, Salome Mack, Till F M Andlauer, Beibei Jiang, Barbara Stiller, Ling Li, Christina Willenborg, Matthias Munz, Thorsten Kessler, Adnan Kastrati, Karl-Ludwig Laugwitz, Jeanette Erdmann, Susanne Moebus, Markus M Nöthen, Annette Peters, Konstantin Strauch, Martina Müller-Nurasyid, Christian Gieger, Thomas Meitinger, Elisabeth Steinhagen-Thiessen, Winfried März, Andres Metspalu, Johan L M Björkegren, Nilesh J Samani, Florian Kronenberg, Bertram Müller-Myhsok, Heribert Schunkert
Cardiovasc Res., 2022 Mar; 118(4): 1088–1102.
Polygenic risk score: a tool ready for clinical use?
Maryam Kavousi, Heribert Schunkert
European Heart Journal, ehab923, Published: 25 February 2022
Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes
Ling Li, Zhifen Chen, Moritz von Scheidt, Shuangyue Li, Andrea Steiner, Ulrich Güldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan, Aldons J. Lusis, Shichao Pang, Thorsten Kessler, Raili Ermel, Katyayani Sukhavasi, Arno Ruusalepp, Julien Gagneur, Jeanette Erdmann, Jason C. Kovacic, Johan L. M. Björkegren, and Heribert Schunkert
Basic Res Cardiol., 2022; 117(1): 6. Published online 2022 Feb 17.
Population-based screening in children for early diagnosis and treatment of familial hypercholesterolemia: design of the VRONI study
Veronika Sanin, Raphael Schmieder, Sara Ates, Lea Dewi Schlieben, Jens Wiehler, Ruoyu Sun, Manuela Decker, Michaela Sander, Stefan Holdenrieder, Florian Kohlmayer, Anna Friedmann, Volker Mall, Therese Feiler, Arne Dreßler, Tim M. Strom, Holger Prokisch, Thomas Meitinger, Moritz von Scheidt, Wolfgang Koenig, Georg Leipold, Heribert Schunkert; on behalf of the DigiMed Bayern Consortium, Bavarian Pediatricians Consortium
European Journal of Public Health, published:15 February 2022
A practical guide to interpreting and generating bottom-up proteomics data visualizations
Julia Patricia Schessner, Eugenia Voytik, Isabell Bludau
Proteomics, First published: 02 February 2022
A Family and a Genome-Wide Polygenic Risk Score Are Independently Associated With Stroke in a Population-Based Study
Michelle Hämmerle, Lukas Forer, , Sebastian Schönherr, Annette Peters, Harald Grallert, PhD, Florian Kronenberg, Christian Gieger, and Claudia Lamina
Stroke, Volume 53, Number 7
Epigenetic scores for the circulating proteome as tools for disease prediction
Danni A Gadd, Robert F Hillary, Daniel L McCartney, Shaza B Zaghlool, Anna J Stevenson, Yipeng Cheng, Chloe Fawns-Ritchie, Cliff Nangle, Archie Campbell, Robin Flaig, Sarah E Harris, Rosie M Walker, Liu Shi, Elliot M Tucker-Drob, Christian Gieger, Annette Peters, Melanie Waldenberger, Johannes Graumann, Allan F McRae, Ian J Deary, David J Porteous, Caroline Hayward, Peter M Visscher, Simon R Cox, Kathryn L Evans, Andrew M McIntosh, Karsten Suhre, Riccardo E Marioni
eLife 2022;11:e71802
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
Johann S. Hawe, Rory Wilson, Katharina T. Schmid, Li Zhou, Lakshmi Narayanan Lakshmanan, Benjamin C. Lehne, Brigitte Kühnel, William R. Scott, Matthias Wielscher, Yik Weng Yew, Clemens Baumbach, Dominic P. Lee, Eirini Marouli, Manon Bernard, Liliane Pfeiffer, Pamela R. Matías-García, Matias I. Autio, Stephane Bourgeois, Christian Herder, Ville Karhunen, Thomas Meitinger, Holger Prokisch, Wolfgang Rathmann, Michael Roden, Sylvain Sebert, Jean Shin, Konstantin Strauch, Weihua Zhang, Wilson L. W. Tan, Stefanie M. Hauck, Juliane Merl-Pham, Harald Grallert, Eudes G. V. Barbosa, MuTHER Consortium, Thomas Illig, Annette Peters, Tomas Paus, Zdenka Pausova, Panos Deloukas, Roger S. Y. Foo, Marjo-Riitta Jarvelin, Jaspal S. Kooner, Marie Loh, Matthias Heinig, Christian Gieger, Melanie Waldenberger & John C. Chambers
Nature Genetics, published: 2022 Jan 03
N-glycosylation of immunoglobulin G predicts incident hypertension
Kifer, Domagoj; Louca, Panayiotis; Cvetko, Ana; Deriš, Helena; Cindrić, Ana; Grallert, Harald; Peters, Annette; Polašek, Ozren; Gornik, Olga; Mangino, Massimo; Spector, Tim D; Valdes, Ana M.; Padmanabhan, Sandosh; Gieger, Christian; Lauc, Gordan; Menni, Cristina
Journal of Hypertension: December 2021 - Volume 39 - Issue 12 - p 2527-2533, Published: 2021 Dec
Polygenic risk for coronary artery disease in the Scottish and English population
Chuhua Yang, Fabian Starnecker, Shichao Pang, Zhifen Chen, Ulrich Güldener, Ling Li, Matthias Heinig, and Heribert Schunkert
BMC Cardiovasc Disord., Published: 2021 Dec 07
Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases
Valentina Paloschi, Maria Sabater-Lleal, Heleen Middelkamp, Aisen Vivas, Sofia Johansson, Andries van der Meer, Maria Tenje, and Lars Maegdefessel
Published: 2021 Dec 01
doi: 10.1093/cvr/cvab088
Cardiovasc Res.
Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease
Katrına D. Neiburga, Baiba Vilne, Sabine Bauer, Dario Bongiovanni, Tilman Ziegler, Mark Lachmann, Simon Wengert, Johann S. Hawe, Ulrich Güldener, Annie M. Westerlund, Ling Li, Shichao Pang, Chuhua Yang, Kathrin Saar, Norbert Huebner, Lars Maegdefessel, DigiMed Bayern Consortium, Rüdiger Lange, Markus Krane, Heribert Schunkert and Moritz von Scheidt
Published: 2021 Nov 12
https://doi.org/10.3390/biom11111683
Biomolecules
Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization
Francesca Fasolo, Hong Jin, Greg Winski, Ekaterina Chernogubova, Jessica Pauli, Hanna Winter, Daniel Y. Li, Nadiya Glukha, Sabine Bauer, Susanne Metschl, Zhiyuan Wu, Marlys L. Koschinsky, Muredach Reilly, Jaroslav Pelisek, Wolfgang Kempf, Hans-Henning Eckstein, Oliver Soehnlein, Ljubica Matic, Ulf Hedin, Alexandra Bäcklund, Claes Bergmark, Valentina Paloschi, and Lars Maegdefessel
Published: 2021 Oct 14
https://doi.org/10.1161/CIRCULATIONAHA.120.052023
Circulation
Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis
Julia Hinterdobler, Simin Schott, Hong Jin, Almut Meesmann, Anna-Lena Steinsiek, Anna-Sophia Zimmermann, Jana Wobst, Philipp Müller, Carina Mauersberger, Baiba Vilne, Alexandra Baecklund, Chien-Sin Chen, Aldo Moggio, Quinte Braster, Michael Molitor, Markus Krane, Wolfgang E Kempf, Karl-Heinz Ladwig, Michael Hristov, Maarten Hulsmans, Ingo Hilgendorf, Christian Weber, Philip Wenzel, Christoph Scheiermann, Lars Maegdefessel, Oliver Soehnlein, Peter Libby, Matthias Nahrendorf, Heribert Schunkert, Thorsten Kessler, and Hendrik B Sager
Published: 2021 Oct 14
doi: 10.1093/eurheartj/ehab371
Eur Heart J.
AlphaMap: an open-source Python package for the visual annotation of proteomics data with sequence-specific knowledge
Eugenia Voytik, Isabell Bludau, Sander Willems, Fynn M Hansen, Andreas-David Brunner, Maximilian T Strauss, Matthias Mann
Published: 29 September 2021
https://doi.org/10.1093/bioinformatics/btab674
Bioinformatics
Risk Prediction of Cardiovascular Events by Exploration of Molecular Data with Explainable Artificial Intelligence
Annie M. Westerlund, Johann S. Hawe, Matthias Heinig, Heribert Schunkert
Published: 24 September 2021
International Journal of Molecular Sciences
AlphaTims: Indexing Trapped Ion Mobility Spectrometry–TOF Data for Fast and Easy Accession and Visualization
Sander Willems, Eugenia Voytik, Patricia Skowronek, Maximilian T. Strauss, and Matthias Mann
Published online: 2021 Sept 17
doi.org/10.1016/j.mcpro.2021.100149
Mol Cell Proteomics.
Genetics of coronary artery disease in the post-GWAS era
Zhifen Chen, Heribert Schunkert
Originally published online 08 July 2021
Journal of Internal Medicine
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study
Alina Bauer, Astrid Zierer, Christian Gieger, Mustafa Büyüközkan, Martina Müller-Nurasyid, Harald Grallert, Christa Meisinger, Konstantin Strauch, Holger Prokisch, Michael Roden, Annette Peters, Jan Krumsiek, Christian Herder, Wolfgang Koenig, Barbara Thorand, Cornelia Huth
Originally published 03 June 2021
Genetic Epidemiology
How Machine Learning and Statistical Models Advance Molecular Diagnostics of Rare Disorders Via Analysis of RNA Sequencing Data
Lea D. Schlieben, Holger Prokisch and Vicente A. Yépez
Originally published 01 June 2021
doi.org/10.3389/fmolb.2021.647277
Front. Mol. Biosci.
Developing an App for Cardiovascular Prevention and Scientific Data Collection
Lara Marie Reimer, Fabian Starnecker, Heribert Schunkert, Stephan Jonas
2021 May 7;279:103-104
Stud Health Technol Inform
Bank, Archiv oder Bibliothek? – Denkmodelle für das ethische Fundament von Biobanken
Banks, archives or libraries? Models for the ethical foundation of biobanks
Therese Feiler, Yannick Schlote, Heribert Schunkert, (Philine Diesselhors, Ulrich Gassner, Florian Kohlmayer, Moritz von Scheidt, Ruoyu Sun, Jens Wiehler), DigiMed Bayern-Konsortium
Originally published 27. April 2021
DOI: 10.1055/a-1294-1291
Dtsch Med Wochenschr 2021; 146(09): 623-626
The Transcription Factor MAFF Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism
Moritz von Scheidt, Yuqi Zhao, Thomas Q. de Aguiar Vallim, Nam Che, Michael Wierer, Marcus M. Seldin, Oscar Franzén, Zeyneb Kurt, Shichao Pang, Dario Bongiovanni, Masayuki Yamamoto, Peter A. Edwards, Arno Ruusalepp, Jason C. Kovacic, Matthias Mann, Johan L.M. Björkegren, Aldons J. Lusis, Xia Yang, and Heribert Schunkert
Originally published 25 Feb 2021
doi.org/10.1161/CIRCULATIONAHA.120.050186
Circulation. 2021;0
Inflammation-Related Risk Loci in Genome-Wide Association Studies of Coronary Artery Disease
Carina Mauersberger, Heribert Schunkert, and Hendrik B. Sager
Originally published 19 Feb 2021
Cells 2021, 10, 440
Untiefen der Gewissheitsproduktion. Sozialwissenschaftliche Überlegungen zum Diagnostischen Screening
Arne Dreßler und Oliver Dimbath
Personalität und praktische Vernunft. Zum Prinzip der Verhältnismäßigkeit in der P4-Medizin und der Corona-Krise
Therese Feiler
Podcast: The Heart in Medicine, History and Culture
Interview with Therese Feiler
Posted on December 10, 2020 by Brandy Schillace
Antihypertensive drugs in COVID-19 infection.
Sara-Joan Pinto-Sietsma, Michael Flossdorf, Veit R Buchholz, Joost Offerhaus, Hidde Bleijendaal, Martijn Beudel, Paul G A Volders, Rachel M A ter Bekke, Tom Dormans, Peter-Paul Zwetsloot, Peter de Jager, Steffen Massberg, Patrick Rämer, Clemens Wendtner, Ellen Hoffmann, Kathrin Rothe, Susanne Feihl, Thorsten Kessler, Yigal M Pinto, Heribert Schunkert
European Heart Journal - Cardiovascular Pharmacotherapy, Volume 6, Issue 6, November 2020, Pages 415–416
Genetically determined intelligence and coronary artery disease risk.
Ling Li, Shichao Pang, Lingyao Zeng, Ulrich Güldener & Heribert Schunkert
Clinical Research in Cardiology (2020)
The Heart in Medicine, History and Culture
Therese Feiler, Joshua Hordern
Med Humanit; 2020;46:352–361.
What's the Damage? Proportionality and the Ethics of Crisis Response
Therese Feiler, Talk given at the ScanBalt-Forum, September 2020
Abstract: The Covid-crisis is perceived as an example of preventive medicine, the chance to install a new digital health economy and to increase cross-border cooperation in terms of medical data exchange. This paper approaches the field from the perspective of ethics, drawing on authors such as Oliver O’Donovan, Francisco de Vitoria and Immanuel Kant. It focusses on the principle of proportionality, which will be revisited both with a view to the Covid-response and personalised medicine. I argue that proportionality tends to be exclusively determined in a forward-looking manner, with reference to a particular aim. However, in order to prevent mission creep, contradictions and subsequent, disproportionate damage, the principle of proportionality also needs to be applied retrospectively. Moral agents need to ask: What is the actual damage? From this, a couple of remarks on P4-medicine and the planned joint declaration of the ScanBalt Forum will follow.
Download: here
Linking obesity with abdominal aortic aneurysm development.
Hans-Henning Eckstein, Lars Maegdefessel
European Heart Journal, Volume 41, Issue 26, 7 July 2020, Pages 2469–2471, doi.org/10.1093/eurheartj/ehz882
Published: 17 December 2019
Bericht zum Ethik-Workshop "Gemeinwohl, Gemeinschaft und Souveränität"
Innerhalb des Projekts findet ein reger Austausch über ethische Fragestellungen und Begrifflichkeiten in Form von regelmäßigen Workshops statt.
Workshop 2, Gemeinwohl, Gemeinschaft und Souveränität fand in verkürzter und digitaler Form am 26. Mai 2020 statt. Einen Bericht finden Sie hier.
Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin
Kathryn T. Hall, Thorsten Kessler, Julie E. Buring, Dani Passow,
Howard D. Sesso, Robert Y. L. Zee, Paul M Ridker, Daniel I. Chasman, and
Heribert Schunkert
European Heart Journal, (2019) 40, 3385–3392
Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease
Lingyao Zeng, Husain A.Talukdar, Simon Koplev, Chiara Giannarelli, Torbjörn Ivert, Li-Ming Gan, Arno Ruusalepp, Eric E. Schadt, Jason C.Kovacic, Aldons J.Lusis, Tom Michoel, Heribert Schunkert, Johan L.M.Björkegren
Journal of the American College of Cardiology, Volume 73, Issue 23, 18 June 2019, Pages 2946-2957