Holger Prokisch

Dr. Holger Prokisch

TUM Klinikum

Dr. Holger Prokisch is the head of the research group “Genetics of Mitochondrial Diseases” at the Institute of Human Genetics, School of Medicine, TUM Klinikum, and the Institute of Neurogenomics, Department of Computational Health, Helmholtz Munich, Germany

Holger Prokisch explores genetic variation in both rare and common diseases with a functional focus on mitochondria-related disease mechanisms. His group was successful in integrating genomic approaches with detailed functional biochemical investigations. Holger Prokisch contributed to the discovery of more than 80 novel disease genes, by applying whole exome and genome sequencing. He extended the diagnostic toolbox by establishing RNA-sequencing and proteomics pipelines for the diagnosis of Mendelian diseases. Much of his work is focused on advanced diagnostics by multi-omics integration. He coordinates the German network for mitochondrial disorders and two Eurasian networks, the GENOMIT network for mitochondrial disorders (EJP RD), and the Personalized Mitochondrial Medicine network, PerMiM (ERA PerMed). In 2024 the German Society of Human Genetics honored Holger Prokisch with its most prestigious award, the GfH Medal of Honour.