Early action, lifelong impact: the crucial role of early detection, risk stratification, and aggressive treatment of familial hypercholesterolaemia

Veronika Sanin, Raphael S Schmieder, Wolfgang Koenig

European Journal of Preventive Cardiology, online publish-ahead-of-print 20 February 2024

doi.org/10.1093/eurjpc/zwae068

Hypertension in the first blood pressure reading and the risk of cardiovascular disease mortality in the general population: findings from the prospective KORA study

Seryan Atasoy , Peter Henningsen, Hamimatunnisa Johar , Martin Middeke, Heribert Sattel, Birgit Linkohr, Ina-Maria Rückert-Eheberg, Margit Heier, Annette Peters, Karl-Heinz Ladwig

J Hypertens,  2024 Mar 1;42(3):521-529.

doi.org/10.1097/HJH.0000000000003629

Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis

Sophia Steigerwald, Ankit Sinha, Kyle L. Fort, Wen-Feng Zeng, Lili Niu, Christoph

Molecular & Cellular Proteomics,  3 January 2024

doi.org/10.1016/j.mcpro.2024.100713

Guideline-Based Cardiovascular Risk Assessment Delivered by an mHealth App: Development Study

Starnecker F, Reimer L, Nissen L, Jovanović M, Kapsecker M, Rospleszcz S, von Scheidt M, Krefting J, Krüger N, Perl B, Wiehler J, Sun R, Jonas S, Schunkert H

JMIR CARDIO, 2023 Dec 8;7:e50813

doi.org/10.2196/50813

IMBAS-MS Discovers Organ-Specific HLA Peptide Patterns in Plasma

Maria Wahle, Marvin Thielert, Maximilian Zwiebel, Patricia Skowronek, Wen-Feng Zeng, Matthias Mann

Mol Cell Proteomics, 2023 Dec 1:100689

doi.org/10.1016/j.mcpro.2023.100689

Unique 40-year survival after heart transplantation with normal graft function and spontaneous operational tolerance

Wolfgang von Scheidt, Bruno Reichart, Bruno Meiser, Moritz von Scheidt, Partho Sen, Florian Schwarz, Eva Harmel, Frank M. Bengel, Andrea Dick, Peter Ueberfuhr, Hermann Reichenspurner, Elmar Jaeckel, Reinhard Schwinzer & Christian Hagl

Res Cardiol, Published 20 November 2023

doi.org/10.1007/s00392-023-02341-x

Utilization of an Artery-on-a-Chip to Unravel Novel Regulators and Therapeutic Targets in Vascular Diseases

Paloschi V, Pauli J, Winski G, Wu Z, Li Z, Botti L, Meucci S, Conti P, Rogowitz F, Glukha N, Hummel N, Busch A, Chernogubova E, Jin H, Sachs N, Eckstein HH, Dueck A, Boon RA, Bausch AR, Maegdefessel L.

Adv Healthc Mater, 2023 Oct 5

doi.org/10.1002/adhm.202302907

Robust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel

Thielert M, Itang EC, Ammar C, Rosenberger FA, Bludau I, Schweizer L, Nordmann TM, Skowronek P, Wahle M, Zeng WF, Zhou XX, Brunner AD, Richter S, Levesque MP, Theis FJ, Steger M, Mann M.

Mol Syst Biol, 2023 Aug 21:e11503 irc Res, 2023 Sep 7

doi.org/10.15252/msb.202211503

ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1

Amin Sharifi M, Wierer M, An Dang T, Milic J, Moggio A, Sachs N, von Scheidt M, Hinterdobler J, Müller P, Werner J, Stiller B, Aherrahrou Z, Erdmann J, Zaliani A, Graettinger M, Reinshagen J, Gul S, Gribbon P, Maegdefessel L, Bernhagen J, Sager HB, Mann M, Schunkert H, Kessler T.

Circ Res, 2023 Sep 7, Epub ahead of print

doi.org/10.1161/CIRCRESAHA.123.322737

Integrative omics approaches to advance raredisease diagnostics

Dmitrii Smirnov,  Nikita Konstantinovskiy,  Holger Prokisch

Journal of Inherited Metabolic Disease, 46:824–838

doi.org/10.1002/jimd.12663

The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms

Fasolo F, Winski G, Li Z, Wu Z, Winter H, Ritzer J, Glukha N, Roy J, Hultgren R, Pauli J, Busch A, Sachs N, Knappich C, Eckstein HH, Boon RA, Paloschi V, Maegdefessel L.

Molecular Therapy: Nucleic Acids, Volume 33, P848-865

doi: https://doi.org/10.1016/j.omtn.2023.08.017

Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques

Scheidt M, Bauer S, Ma A, Hao K, Kessler T, Vilne B, Wang Y, Hodonsky CJ, Ghosh SKB, Mokry M, Gao H, Kawai K, Sakamoto A, Kaiser J, Bongiovanni D, Fleig J, Oldenbuettel L, Chen Z, Moggio A, Sager HB, Hecker JS, Bassermann F, Maegdefessel L, Miller CL, Koenig W, Zeiher AM, Dimmeler S, Graw M, Braun C, Ruusalepp A, Leeper NJ

medRxiv, [Preprint]. 2023 Jul

doi.org/10.1101/2023.07.22.23292754

Medikalisierte Lebensführung und soziale Ungleichheit. Kooperationsperspektiven von P4-Medizin und Sozialer Arbeit

Arne Dreßler, Oliver Dimbath

In: Schübel, Thomas/Friele, Boris (Hg.): Medikalisierung und Soziale Arbeit, Springer VS, S. 203–221

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Long non-coding RNAs at the crossroad of vascular smooth muscle cell phenotypic modulation in atherosclerosis and neointimal formation

Francesca Fasolo, Valentina Paloschi, Lars Maegdefessel

Atherosclerosis, 374, 34-43

doi.org/10.1016/j.atherosclerosis.2022.11.021

Accurate label-free quantification by directLFQ to compare unlimited numbers of proteomes

Constantin Ammar, Julia Patricia Schessner, Sander Willems, André C. Michaelis, Matthias Mann

Molecular & Cellular Proteomics, pe proof

doi.org/10.1016/j.mcpro.2023.100581

E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1

Mulorz J, Spin JM, Mulorz P, Wagenhäuser MU, Deng A, Mattern K, Rhee YH, Toyama K, Adam M, Schelzig H, Maegdefessel L, Tsao PS.

Cardiovascular Research, 119, 867–878

doi.org/10.1093/cvr/cvac173

Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression

Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, Bäcklund A, Khomtchouk BB, Van Booven DJ, Sachs N, Eckstein H-H, Wittig I, Boon RA, Jin H, Maegdefessel L

Molecular Therapy (2023, pre proof)

doi.org/10.1016/j.ymthe.2023.04.020

Use of big data from health insurance for assessment of cardiovascular outcomes

Johannes Krefting, Partho Sen, Diana David-Rus, Ulrich Güldener, Johann S Hawe, Moritz Von Scheidt, Salvatore Cassese, Heribert Schunkert.

Front. Artif. Intell. Sec. Medicine and Public Health, Volume 6 - 2023

doi.org/10.3389/frai.2023.1155404

Machine Learning Identifies New Predictors on Restenosis Risk after Coronary Artery Stenting in 10,004 Patients with Surveillance Angiography

Güldener, Ulrich, Thorsten Kessler, Moritz von Scheidt, Johann S. Hawe, Beatrix Gerhard, Dieter Maier, Mark Lachmann, Karl-Ludwig Laugwitz, Salvatore Cassese, Albert W. Schömig, Adnan Kastrati and Heribert Schunkert

Journal of Clinical Medicine, 2023; 12(8):2941

doi.org/10.3390/jcm12082941

A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study

Duschek E, Forer L, Schönherr S, Gieger C, Peters A, Kronenberg F, Grallert H, Lamina C.

Sci Rep., 2023 Mar 23;13(1):4805.

 doi.org/10.1038/s41598-023-31496-w

Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations

Thareja G, Belkadi A, Arnold M, Albagha OME, Graumann J, Schmidt F, Grallert H, Peters A, Gieger C, Consortium TQGPR, Suhre K.

Hum Mol Genet, 2023 Mar 6;32(6):907-916

doi.org/10.1093/hmg/ddac243

Kontrollmedizin und Patientenautonomie. Das Freiheitsproblem in der gesundheitsorientierten medizinischen Versorgung, speziell bei der Einführung von Screenings.
Ein Dialog zwischen Allgemeiner Soziologie und Medizinsoziologie

Arne Dreßler und Oliver Dimbath

TTN Edition 2023 Freiheit, Institut Technik-Theologie-Naturwissenschaften (TTN)
an der Ludwig-Maximilians-Universität, Pages 25-41

https://www.ttn.st.evtheol.uni-muenchen.de/publikationen/ttn_edition/ttn_edition_2023_freiheit.pdf

Chapter 10 - Genetics of mitochondrial diseases: Current approaches for the molecular diagnosis

Lea D. Schlieben, Holger Prokisch

Handbook of Clinical Neurology, Elsevier, Volume 194, 2023, Pages 141-165

doi.org/10.1016/B978-0-12-821751-1.00011-7

Genetic and modifiable risk factors combine multiplicatively in common disease

Pang S, Yengo L, Nelson CP, Bourier F, Zeng L, Li L, Kessler T, Erdmann J, Mägi R, Läll K, Metspalu A, Mueller-Myhsok B, Samani NJ, Visscher PM, Schunkert H

Clinical Research in Cardiology, 2023 Feb;112(2):247-257

doi.org/10.1007/s00392-022-02081-4

Synchro-PASEF allows precursor-specific fragment ion extraction and interference removal in data-independent acquisition

Skowronek P, Krohs F, Lubeck M, Wallmann G, Itang ECM, Koval P, Wahle M, Thielert M, Meier F, Willems S, Raether O, Mann M.

IMol Cell Proteomics, 2022 Dec 21:100489

doi.org/10.1016/j.mcpro.2022.100489

Quo Vadis? Immunodynamics of Myeloid Cells after Myocardial Infarction

Moggio A, Schunkert H, Kessler T, Sager HB.

Int J Mol Sci, 2022 Dec 13;23(24)

doi.org/10.3390/ijms232415814

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million  participants

Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M, Hindy G, Zhou W, Grace C, Roselli C, Marston NA, Kamanu FK, Surakka I, Venegas LM, Sherliker P, Koyama S, Ishigaki K, Åsvold BO, Brown MR, Brumpton B, de Vries PS, Giannakopoulou O, Giardoglou P, Gudbjartsson DF, Güldener U, Haider SMI, Helgadottir A, Ibrahim M, Kastrati A, Kessler T, Kyriakou T, Konopka T, Li L, Ma L, Meitinger T, Mucha S, Munz M, Murgia F, Nielsen JB, Nöthen MM, Pang S, Reinberger T, Schnitzler G, Smedley D, Thorleifsson G, von Scheidt M, Ulirsch JC; Biobank Japan; EPIC-CVD, Arnar DO, Burtt NP, Costanzo MC, Flannick J, Ito K, Jang DK, Kamatani Y, Khera AV, Komuro I, Kullo IJ, Lotta LA, Nelson CP, Roberts R, Thorgeirsson G, Thorsteinsdottir U, Webb TR, Baras A, Björkegren JLM, Boerwinkle E, Dedoussis G, Holm H, Hveem K, Melander O, Morrison AC, Orho-Melander M, Rallidis LS, Ruusalepp A, Sabatine MS, Stefansson K, Zalloua P, Ellinor PT, Farrall M, Danesh J, Ruff CT, Finucane HK, Hopewell JC, Clarke R, Gupta RM, Erdmann J, Samani NJ, Schunkert H, Watkins H, Willer CJ, Deloukas P, Kathiresan S, Butterworth AS; CARDIoGRAMplusC4D Consortium.

Nature Genetics, 54, pages 1803–1815 (2022)

doi.org/10.1038/s41588-022-01233-6

Linking single nucleotide polymorphisms to signaling blueprints in abdominal aortic aneurysms

Lim C, Pratama MY, Rivera C, Silvestro M, Tsao PS, Maegdefessel L, Gallagher KA, Maldonado T, Ramkhelawon B.

Scientific Reports, 2022 Dec 5;12(1):20990.

doi.org/10.1038/s41598-022-25144-y

Radikale Medikalisierung: P4-Medizin als gesellschaftliches Modernisierungsprogramm

Arne Dreßler und Oliver Dimbath

Psychologie & Gesellschaftskritik, 46 (3), 91–110

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Interleukin-1b suppression dampens inflammatory leucocyte production and uptake in atherosclerosis

Hettwer J, Hinterdobler J, Miritsch B, Deutsch MA, Li X, Mauersberger C, Moggio A, Braster Q, Gram H, Robertson AAB, Cooper MA, Groß O, Krane M, Weber C, Koenig W, Soehnlein O, Adamstein NH, Ridker P, Schunkert H, Libby P, Kessler T, Sager HB.

Cardiovascular Research, 2022 Oct 21;118(13):2778-2791

doi.org/10.1093/cvr/cvab337

Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease

Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, Liu L, Ul Ain Q, Ehreiser V, Weber C, Kilani B, Mertsch P, Götschke J, Cremer S, Fu W, Lorenz M, Ishikawa-Ankerhold H, Raatz E, El-Nemr S, Görlach A, Marhuenda E, Stark K, Pircher J, Stegner D, Gieger C, Schmidt-Supprian M, Gaertner F, Almendros I, Kelm M, Schulz C, Hidalgo A, Massberg S.

Immunity, 2022 Oct 18:S1074-7613(22)00542-8

doi.org/10.1016/j.immuni.2022.10.001

Genotypic and phenotypic spectrum of infantile liver failure due to pathogenic TRMU variants

Vogel GF, Mozer-Glassberg Y, Landau YE, Schlieben LD, Prokisch H, Feichtinger RG, Mayr JA, Brennenstuhl H, Schröter J, Pechlaner A, Alkuraya FS, Baker JJ, Barcia G, Baric I, Braverman N, Burnyte B, Christodoulou J, Ciara E, Coman D, Das AM, Darin N, Della Marina A, Distelmaier F, Eklund EA, Ersoy M, Fang W, Gaignard P, Ganetzky RD, Gonzales E, Howard C, Hughes J, Konstantopoulou V, Kose M, Kerr M, Khan A, Lenz D, McFarland R, Margolis MG, Morrison K, Müller T, Murayama K, Nicastro E, Pennisi A, Peters H, Piekutowska-Abramczuk D, Rötig A, Santer R, Scaglia F, Schiff M, Shagrani M, Sharrard M, Soler-Alfonso C, Staufner C, Storey I, Stormon M, Taylor RW, Thorburn DR, Teles EL, Wang JS, Weghuber D, Wortmann S.

Genet Med,  2022 Oct 28:S1098-3600(22)00953-4

doi.org/10.1016/j.gim.2022.09.015

Rapid and In-Depth Coverage of the (Phospho-)Proteome With Deep Libraries and Optimal Window Design for dia-PASEF

Skowronek P, Thielert M, Voytik E, Tanzer MC, Hansen FM, Willems S, Karayel O, Brunner AD, Meier F, Mann M

 Mol Cell Proteomics,  2022 Sep;21(9)

doi.org/10.1016/j.mcpro.2022.100279

Identification of risk loci for primary aldosteronism in genome-wide association studies

Le Floch E, Cosentino T, Larsen CK, Beuschlein F, Reincke M, Amar L, Rossi GP, De Sousa K, Baron S, Chantalat S, Saintpierre B, Lenzini L, Frouin A, Giscos-Douriez I, Ferey M, Abdellatif AB, Meatchi T, Empana JP, Jouven X, Gieger C, Waldenberger M, Peters A, Cusi D, Salvi E, Meneton P, Touvier M, Deschasaux M, Druesne-Pecollo N, Boulkroun S, Fernandes-Rosa FL, Deleuze JF, Jeunemaitre X, Zennaro MC

 Nat Commun, 2022 Sep 3;13(1):5198

 doi.org/10.1038/s41467-022-32896-8

Association of In-Hospital Hemoglobin Drop With Decreased Myocardial Salvage and Increased Long-Term Mortality in Patients With Acute ST-Segment-Elevation Myocardial Infarction

Dutsch A, Graesser C, Voll F, Novacek S, Eggerstedt R, Armbruster NL, Laugwitz KL, Cassese S, Schunkert H, Ndrepepa G, Kastrati A, Kessler T, Sager HB

J Am Heart Assoc, 2022 Sep 6;11(17)

doi.org/10.1161/JAHA.121.024857

Genetic and modifiable risk factors combine multiplicatively in common disease

Pang S, Yengo L, Nelson CP, Bourier F, Zeng L, Li L, Kessler T, Erdmann J, Mägi R, Läll K, Metspalu A, Mueller-Myhsok B, Samani NJ, Visscher PM, Schunkert H.

Clinical Research in Cardiology, 2022 Aug 20

 doi.org/10.1007/s00392-022-02081-4

Colchicine Impacts Leukocyte Trafficking in Atherosclerosis and Reduces Vascular Inflammation

Meyer-Lindemann U, Mauersberger C, Schmidt AC, Moggio A, Hinterdobler J, Li X, Khangholi D, Hettwer J, Gräßer C, Dutsch A, Schunkert H, Kessler T, Sager HB.

Front Immunol., 2022 Jul 4; 13:898690

doi: 10.3389/fimmu.2022.898690

AlphaPeptDeep: A modular deep learning framework to predict peptide properties for proteomics

Wen-Feng Zeng, Xie-Xuan Zhou, Sander Willems, Constantin Ammar, Maria Wahle, Isabell Bludau, Eugenia Voytik, Maximillian T. Strauss and Matthias Mann.

bioRxiv preprint, online posted July 16, 2022

doi: 10.1101/2022.07.14.499992

Association between a polygenic and family risk score on the prevalence and incidence of myocardial infarction in the KORA-F3 study

Florian Schnitzer, Lukas Forer, Sebastian Schönherr, Christian Gieger, Harald Grallert, Florian Kronenberg, Annette Peters, Claudia Lamina

atherosclerosis, Volume 352, P10-17, July 01, 2022

doi.org/10.1016/j.atherosclerosis.2022.05.014

Guidelines for clinical interpretation of variant pathogenicity using RNA phenotypes

Dmitrii Smirnov, Lea D. Schlieben, Fatemeh Peymani, Riccardo Berutti, Holger Prokisch

Human Mutation Variation, Informatics and Disease. 29 May 2022

doi.org/10.1002/humu.24416

The structural context of posttranslational modifications at a proteome-wide scale

Isabell Bludau, Sander Willems, Wen-Feng Zeng, Maximilian T. Strauss, Fynn M. Hansen, Maria C. Tanzer, Ozge Karayel, Brenda A. Schulman, Matthias Mann

PLOS Biology. May 16, 2022

doi.org/10.1371/journal.pbio.3001636

Validation of the 30-Year Framingham Risk Score in a German Population-Based Cohort

Rospleszcz S, Starnecker F, Linkohr B, von Scheidt M, Gieger C, Schunkert H, Peters A; DigiMed Bayern Consortium.

Diagnostics (Basel). 2022 Apr 12;12(4):965.

doi.org/10.3390/diagnostics12040965

Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases

Li Y, Cheng Y, Consolato F, Schiano G, Chong MR, Pietzner M, Nguyen NQH, Scherer N, Biggs ML, Kleber ME, Haug S, Göçmen B, Pigeyre M, Sekula P, Steinbrenner I, Schlosser P, Joseph CB, Brody JA, Grams ME, Hayward C, Schultheiss UT, Krämer BK, Kronenberg F, Peters A, Seissler J, Steubl D, Then C, Wuttke M, März W, Eckardt KU, Gieger C, Boerwinkle E, Psaty BM, Coresh J, Oefner PJ, Pare G, Langenberg C, Scherberich JE, Yu B, Akilesh S, Devuyst O, Rampoldi L, Köttgen A.

JCI Insight. 2022 Apr 21;e157035.

doi.org/10.1172/jci.insight.157035

Clinical implementation of RNA sequencing for Mendelian disease diagnostics

Yépez VA, Gusic M, Kopajtich R, Mertes C, Smith NH, Alston CL, Ban R, Beblo S, Berutti R, Blessing H, Ciara E, Distelmaier F, Freisinger P, Häberle J, Hayflick SJ, Hempel M, Itkis YS, Kishita Y, Klopstock T, Krylova TD, Lamperti C, Lenz D, Makowski C, Mosegaard S, Müller MF, Muñoz-Pujol G, Nadel A, Ohtake A, Okazaki Y, Procopio E, Schwarzmayr T, Smet J, Staufner C, Stenton SL, Strom TM, Terrile C, Tort F, Van Coster R, Vanlander A, Wagner M, Xu M, Fang F, Ghezzi D, Mayr JA, Piekutowska-Abramczuk D, Ribes A, Rötig A, Taylor RW, Wortmann SB, Murayama K, Meitinger T, Gagneur J, Prokisch H.

Genome Med. 2022; 14: 38.

doi.org/10.1186/s13073-022-01019-9

Cis-epistasis at the LPA locus and risk of cardiovascular diseases

Lingyao Zeng, Sylvain Moser, Nazanin Mirza-Schreiber, Claudia Lamina, Stefan Coassin, Christopher P Nelson, Tarmo Annilo, Oscar Franzén, Marcus E Kleber, Salome Mack, Till F M Andlauer, Beibei Jiang, Barbara Stiller, Ling Li, Christina Willenborg, Matthias Munz, Thorsten Kessler, Adnan Kastrati, Karl-Ludwig Laugwitz, Jeanette Erdmann, Susanne Moebus, Markus M Nöthen, Annette Peters, Konstantin Strauch, Martina Müller-Nurasyid, Christian Gieger, Thomas Meitinger, Elisabeth Steinhagen-Thiessen, Winfried März, Andres Metspalu, Johan L M Björkegren, Nilesh J Samani, Florian Kronenberg, Bertram Müller-Myhsok, Heribert Schunkert

Cardiovasc Res., 2022 Mar; 118(4): 1088–1102.

doi.org/10.1093/cvr/cvab136

Polygenic risk score: a tool ready for clinical use?

Maryam Kavousi, Heribert Schunkert

European Heart Journal, ehab923, Published: 25 February 2022

doi.org/10.1093/eurheartj/ehab923

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes

Ling Li, Zhifen Chen, Moritz von Scheidt, Shuangyue Li, Andrea Steiner, Ulrich Güldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan, Aldons J. Lusis, Shichao Pang, Thorsten Kessler, Raili Ermel, Katyayani Sukhavasi, Arno Ruusalepp, Julien Gagneur, Jeanette Erdmann, Jason C. Kovacic, Johan L. M. Björkegren, and Heribert Schunkert

Basic Res Cardiol., 2022; 117(1): 6. Published online 2022 Feb 17.

doi.org/10.1007/s00395-022-00917-8

Population-based screening in children for early diagnosis and treatment of familial hypercholesterolemia: design of the VRONI study

Veronika Sanin, Raphael Schmieder, Sara Ates, Lea Dewi Schlieben, Jens Wiehler, Ruoyu Sun, Manuela Decker, Michaela Sander, Stefan Holdenrieder, Florian Kohlmayer, Anna Friedmann, Volker Mall, Therese Feiler, Arne Dreßler, Tim M. Strom, Holger Prokisch, Thomas Meitinger, Moritz von Scheidt, Wolfgang Koenig, Georg Leipold, Heribert Schunkert; on behalf of the DigiMed Bayern Consortium, Bavarian Pediatricians Consortium

European Journal of Public Health, published:15 February 2022

doi.org/10.1093/eurpub/ckac007

A practical guide to interpreting and generating bottom-up proteomics data visualizations

Julia Patricia Schessner, Eugenia Voytik, Isabell Bludau

Proteomics, First published: 02 February 2022

doi.org/10.1002/pmic.202100103

Epigenetic scores for the circulating proteome as tools for disease prediction

Danni A Gadd, Robert F Hillary, Daniel L McCartney, Shaza B Zaghlool, Anna J Stevenson, Yipeng Cheng, Chloe Fawns-Ritchie, Cliff Nangle, Archie Campbell, Robin Flaig, Sarah E Harris, Rosie M Walker, Liu Shi, Elliot M Tucker-Drob, Christian Gieger, Annette Peters, Melanie Waldenberger, Johannes Graumann, Allan F McRae, Ian J Deary, David J Porteous, Caroline Hayward, Peter M Visscher, Simon R Cox, Kathryn L Evans, Andrew M McIntosh, Karsten Suhre, Riccardo E Marioni 

eLife 2022;11:e71802

doi.org/10.7554/eLife.71802

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

Johann S. Hawe, Rory Wilson, Katharina T. Schmid, Li Zhou, Lakshmi Narayanan Lakshmanan, Benjamin C. Lehne, Brigitte Kühnel, William R. Scott, Matthias Wielscher, Yik Weng Yew, Clemens Baumbach, Dominic P. Lee, Eirini Marouli, Manon Bernard, Liliane Pfeiffer, Pamela R. Matías-García, Matias I. Autio, Stephane Bourgeois, Christian Herder, Ville Karhunen, Thomas Meitinger, Holger Prokisch, Wolfgang Rathmann, Michael Roden, Sylvain Sebert, Jean Shin, Konstantin Strauch, Weihua Zhang, Wilson L. W. Tan, Stefanie M. Hauck, Juliane Merl-Pham, Harald Grallert, Eudes G. V. Barbosa, MuTHER Consortium, Thomas Illig, Annette Peters, Tomas Paus, Zdenka Pausova, Panos Deloukas, Roger S. Y. Foo, Marjo-Riitta Jarvelin, Jaspal S. Kooner, Marie Loh, Matthias Heinig, Christian Gieger, Melanie Waldenberger & John C. Chambers

Nature Genetics, published: 2022 Jan 03

doi.org/10.1038/s41588-021-00969-x

N-glycosylation of immunoglobulin G predicts incident hypertension

Kifer, Domagoj; Louca, Panayiotis; Cvetko, Ana; Deriš, Helena; Cindrić, Ana; Grallert, Harald; Peters, Annette; Polašek, Ozren; Gornik, Olga; Mangino, Massimo; Spector, Tim D; Valdes, Ana M.; Padmanabhan, Sandosh; Gieger, Christian; Lauc, Gordan; Menni, Cristina

Journal of Hypertension: December 2021 - Volume 39 - Issue 12 - p 2527-2533, Published: 2021 Dec

doi.org/10.1097/HJH.0000000000002963

Polygenic risk for coronary artery disease in the Scottish and English population

Chuhua Yang, Fabian Starnecker, Shichao Pang, Zhifen Chen, Ulrich Güldener, Ling Li, Matthias Heinig, and Heribert Schunkert

BMC Cardiovasc Disord., Published: 2021 Dec 07

doi.org/10.1186/s12872-021-02398-4

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases

Valentina Paloschi, Maria Sabater-Lleal, Heleen Middelkamp, Aisen Vivas, Sofia Johansson, Andries van der Meer, Maria Tenje, and Lars Maegdefessel

Published: 2021 Dec 01

doi: 10.1093/cvr/cvab088

Cardiovasc Res.

Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease

Katrına D. Neiburga, Baiba Vilne, Sabine Bauer, Dario Bongiovanni, Tilman Ziegler, Mark Lachmann, Simon Wengert, Johann S. Hawe, Ulrich Güldener, Annie M. Westerlund, Ling Li, Shichao Pang, Chuhua Yang, Kathrin Saar, Norbert Huebner, Lars Maegdefessel, DigiMed Bayern Consortium, Rüdiger Lange, Markus Krane, Heribert Schunkert and Moritz von Scheidt

Published: 2021 Nov 12

https://doi.org/10.3390/biom11111683

Biomolecules

Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization

Francesca Fasolo, Hong Jin, Greg Winski, Ekaterina Chernogubova, Jessica Pauli, Hanna Winter, Daniel Y. Li, Nadiya Glukha, Sabine Bauer, Susanne Metschl, Zhiyuan Wu, Marlys L. Koschinsky, Muredach Reilly, Jaroslav Pelisek, Wolfgang Kempf, Hans-Henning Eckstein, Oliver Soehnlein, Ljubica Matic, Ulf Hedin, Alexandra Bäcklund, Claes Bergmark, Valentina Paloschi, and Lars Maegdefessel

Published: 2021 Oct 14

https://doi.org/10.1161/CIRCULATIONAHA.120.052023

Circulation

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis

Julia Hinterdobler, Simin Schott, Hong Jin, Almut Meesmann, Anna-Lena Steinsiek, Anna-Sophia Zimmermann, Jana Wobst, Philipp Müller, Carina Mauersberger, Baiba Vilne, Alexandra Baecklund, Chien-Sin Chen, Aldo Moggio, Quinte Braster, Michael Molitor, Markus Krane, Wolfgang E Kempf, Karl-Heinz Ladwig, Michael Hristov, Maarten Hulsmans, Ingo Hilgendorf, Christian Weber, Philip Wenzel, Christoph Scheiermann, Lars Maegdefessel, Oliver Soehnlein, Peter Libby, Matthias Nahrendorf, Heribert Schunkert, Thorsten Kessler, and Hendrik B Sager

Published: 2021 Oct 14

doi: 10.1093/eurheartj/ehab371

Eur Heart J.

AlphaMap: an open-source Python package for the visual annotation of proteomics data with sequence-specific knowledge

Eugenia Voytik, Isabell Bludau, Sander Willems, Fynn M Hansen, Andreas-David Brunner, Maximilian T Strauss, Matthias Mann

Published: 29 September 2021

https://doi.org/10.1093/bioinformatics/btab674

Bioinformatics

Risk Prediction of Cardiovascular Events by Exploration of Molecular Data with Explainable Artificial Intelligence

Annie M. Westerlund, Johann S. Hawe, Matthias Heinig, Heribert Schunkert

Published: 24 September 2021

doi.org/10.3390/ijms221910291

International Journal of Molecular Sciences

AlphaTims: Indexing Trapped Ion Mobility Spectrometry–TOF Data for Fast and Easy Accession and Visualization

Sander Willems, Eugenia Voytik, Patricia Skowronek, Maximilian T. Strauss, and Matthias Mann

Published online: 2021 Sept 17

doi.org/10.1016/j.mcpro.2021.100149

Mol Cell Proteomics.

Genetics of coronary artery disease in the post-GWAS era

Zhifen Chen, Heribert Schunkert

Originally published online 08 July 2021

doi.org/10.1111/joim.13362

Journal of Internal Medicine

Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study

Alina Bauer, Astrid Zierer, Christian Gieger, Mustafa Büyüközkan, Martina Müller-Nurasyid, Harald Grallert, Christa Meisinger, Konstantin Strauch, Holger Prokisch, Michael Roden, Annette Peters, Jan Krumsiek, Christian Herder, Wolfgang Koenig, Barbara Thorand, Cornelia Huth

Originally published 03 June 2021

doi.org/10.1002/gepi.22389

Genetic Epidemiology

How Machine Learning and Statistical Models Advance Molecular Diagnostics of Rare Disorders Via Analysis of RNA Sequencing Data

Lea D. Schlieben, Holger Prokisch and Vicente A. Yépez

Originally published 01 June 2021

doi.org/10.3389/fmolb.2021.647277

Front. Mol. Biosci.

Developing an App for Cardiovascular Prevention and Scientific Data Collection

Lara Marie Reimer, Fabian Starnecker, Heribert Schunkert, Stephan Jonas

2021 May 7;279:103-104

doi: 10.3233/SHTI210095

Stud Health Technol Inform

Bank, Archiv oder Bibliothek? – Denkmodelle für das ethische Fundament von Biobanken
Banks, archives or libraries? Models for the ethical foundation of biobanks

Therese Feiler, Yannick Schlote, Heribert Schunkert, (Philine Diesselhors, Ulrich Gassner, Florian Kohlmayer, Moritz von Scheidt, Ruoyu Sun, Jens Wiehler), DigiMed Bayern-Konsortium

Originally published 27. April 2021

DOI: 10.1055/a-1294-1291

Dtsch Med Wochenschr 2021; 146(09): 623-626

The Transcription Factor MAFF Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism

Moritz von Scheidt, Yuqi Zhao, Thomas Q. de Aguiar Vallim, Nam Che, Michael Wierer, Marcus M. Seldin, Oscar Franzén, Zeyneb Kurt, Shichao Pang, Dario Bongiovanni, Masayuki Yamamoto, Peter A. Edwards, Arno Ruusalepp, Jason C. Kovacic, Matthias Mann, Johan L.M. Björkegren, Aldons J. Lusis, Xia Yang, and Heribert Schunkert

Originally published 25 Feb 2021

doi.org/10.1161/CIRCULATIONAHA.120.050186

Circulation. 2021;0

Inflammation-Related Risk Loci in Genome-Wide Association Studies of Coronary Artery Disease

Carina Mauersberger, Heribert Schunkert, and Hendrik B. Sager

Originally published 19 Feb 2021

doi: 10.3390/cells10020440

Cells 2021, 10, 440

TTN edition 2021: Vernunft und Wissen. Zur Ethik in der Krise.

Herausgegeben von Therese Feiler. Mit Beiträgen von Yannick Schlote, Oliver Dimbath und Arne Dreßler, Sebastian Kistler, Stephan Schleissing, Hendrik-Meyer Magister und Therese Feiler.

TTN edition ist die digitale Publikationsreihe des Instituts. Im TTN edition werden regelmäßig Texte und Beiträge veröffentlicht, die anregungsreiche und überzeugende Argumente zum weiten Themenfeld der angewandten Ethik sowie zu den TTN-Schwerpunkten erarbeiten.

Podcast: The Heart in Medicine, History and Culture

Interview with Therese Feiler

Posted on December 10, 2020 by Brandy Schillace

Antihypertensive drugs in COVID-19 infection.

Sara-Joan Pinto-Sietsma, Michael Flossdorf, Veit R Buchholz, Joost Offerhaus, Hidde Bleijendaal, Martijn Beudel, Paul G A Volders, Rachel M A ter Bekke, Tom Dormans, Peter-Paul Zwetsloot, Peter de Jager, Steffen Massberg, Patrick Rämer, Clemens Wendtner, Ellen Hoffmann, Kathrin Rothe, Susanne Feihl, Thorsten Kessler, Yigal M Pinto, Heribert Schunkert

European Heart Journal - Cardiovascular Pharmacotherapy, Volume 6, Issue 6, November 2020, Pages 415–416

Genetically determined intelligence and coronary artery disease risk.

Ling Li, Shichao Pang, Lingyao Zeng, Ulrich Güldener & Heribert Schunkert

Clinical Research in Cardiology (2020)

The Heart in Medicine, History and Culture

Therese Feiler, Joshua Hordern

Med Humanit; 2020;46:352–361.

What's the Damage? Proportionality and the Ethics of Crisis Response

Therese Feiler, Talk given at the ScanBalt-Forum, September 2020

Abstract: The Covid-crisis is perceived as an example of preventive medicine, the chance to install a new digital health economy and to increase cross-border cooperation in terms of medical data exchange. This paper approaches the field from the perspective of ethics, drawing on authors such as Oliver O’Donovan, Francisco de Vitoria and Immanuel Kant. It focusses on the principle of proportionality, which will be revisited both with a view to the Covid-response and personalised medicine. I argue that proportionality tends to be exclusively determined in a forward-looking manner, with reference to a particular aim. However, in order to prevent mission creep, contradictions and subsequent, disproportionate damage, the principle of proportionality also needs to be applied retrospectively. Moral agents need to ask: What is the actual damage? From this, a couple of remarks on P4-medicine and the planned joint declaration of the ScanBalt Forum will follow.

Download: here

Linking obesity with abdominal aortic aneurysm development.

Hans-Henning Eckstein, Lars Maegdefessel

European Heart Journal, Volume 41, Issue 26, 7 July 2020, Pages 2469–2471, doi.org/10.1093/eurheartj/ehz882
Published: 17 December 2019

Bericht zum Ethik-Workshop "Gemeinwohl, Gemeinschaft und Souveränität"

Innerhalb des Projekts findet ein reger Austausch über ethische Fragestellungen und Begrifflichkeiten in Form von regelmäßigen Workshops statt.
Workshop 2, Gemeinwohl, Gemeinschaft und Souveränität fand in verkürzter und digitaler Form am 26. Mai 2020 statt. Einen Bericht finden Sie hier.

Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease

Lingyao Zeng, Husain A.Talukdar, Simon Koplev, Chiara Giannarelli, Torbjörn Ivert, Li-Ming Gan, Arno Ruusalepp, Eric E. Schadt, Jason C.Kovacic, Aldons J.Lusis, Tom Michoel, Heribert Schunkert, Johan L.M.Björkegren

Journal of the American College of Cardiology, Volume 73, Issue 23, 18 June 2019, Pages 2946-2957

TTN edition 2019: Gemeinwohl, Polis, Individuum. Bioethik im Kontext.

Herausgegeben von Therese Feiler. Mit Beiträgen von Yannick Schlote, Hendrik Meyer-Magister, Therese Feiler und Niklas Schleicher.

TTN edition ist die digitale Publikationsreihe des Instituts. Im TTN edition werden regelmäßig Texte und Beiträge veröffentlicht, die anregungsreiche und überzeugende Argumente zum weiten Themenfeld der angewandten Ethik sowie zu den TTN-Schwerpunkten erarbeiten.